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antipsychotic

American  
[an-tee-sahy-kot-ik, an-tahy-] / ˌæn ti saɪˈkɒt ɪk, ˌæn taɪ- /

adjective

  1. of or relating to any of various substances used in the treatment of psychosis, especially schizophrenia, and acute or severe states of mania, depression, or paranoia.


noun

  1. Also called neuroleptic.  Also called major tranquilizer.  any such substance, as the phenothiazines.

antipsychotic British  
/ ˌæntɪsaɪˈkɒtɪk /

adjective

  1. preventing or treating psychosis

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

noun

  1. any antipsychotic drug, such as chlorpromazine: used to treat such conditions as schizophrenia

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of antipsychotic

First recorded in 1950–55; anti- + psychotic

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

“Medical directors failed to prevent inappropriate use of antipsychotic drugs,” and “nursing home pharmacists failed to identify medical concerns and did not recommend dose reductions.”

From MarketWatch • Apr. 7, 2026

Risperidone is a powerful antipsychotic often prescribed to dementia patients who experience severe agitation or aggressive behavior.

From Science Daily • Mar. 8, 2026

Patients can be supported and treated with a mix of antipsychotic medications, talking therapies and family support.

From BBC • Dec. 10, 2025

An antipsychotic, risperidone, when she was 15 made her sick and put her in the hospital.

From The Wall Street Journal • Nov. 20, 2025

An assortment of antipsychotic medicines was prescribed, and he improved gradually—but never enough, apparently, to merit discharge.

From "The Gene" by Siddhartha Mukherjee

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