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atrophy

American  
[a-truh-fee] / ˈæ trə fi /

noun

  • atrophies
    plural
  1. Pathology. Also atrophia a wasting away of the body or of an organ or part, as from defective nutrition or nerve damage.

  2. degeneration, decline, or decrease, as from disuse.

    He argued that there was a progressive atrophy of freedom and independence of thought.


verb (used with or without object)

  • atrophies,
    present (3rd person singular)
  • atrophied,
    past participle,  past
  • atrophying
    present participle
  1. to affect with or undergo atrophy.

atrophy British  
/ ˈætrəfɪ /

noun

  1. a wasting away of an organ or part, or a failure to grow to normal size as the result of disease, faulty nutrition, etc

  2. any degeneration or diminution, esp through lack of use

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to waste away or cause to waste away

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
atrophy Scientific  
/ ăt′rə-fē /
  1. A wasting or decrease in the size of an organ or tissue, as from death and reabsorption of cells, diminished proliferation of cells, pressure, lack of oxygen, malnutrition, decreased function, or hormonal changes.


atrophy Cultural  
  1. The wasting away or decrease in size of an organ or tissue in the body. When a body part is affected by paralysis, the muscles may atrophy through lack of use.


Discover More

The term is also used in a more general way to refer to a wasting process: “Since he stopped playing, his piano skills have atrophied.”

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Etymology

Origin of atrophy

First recorded in 1590–1600; earlier atrophie, from Middle French, from Late Latin atrophia, from Greek, from átroph(os) “not fed, unnourished” (from a- a- 6 + troph(ḗ) “nourishment” + -os, adjective suffix; see tropho-) + -ia -ia

Explanation

Wearing a cast on a broken leg can cause atrophy, or withering, in the leg, because it is immobilized and gets no exercise. Appearing in English in the 17th century, the word atrophy originally described a lack of nourishment. Atrophy occurs in parts of the body that can't move or be "fed" because of disease or injury. It also is used to describe things that go dull through lack of use, like skills in sports or artistic creativity. The (unrelated) word "trophy" refers to something that sits on a shelf and is admired, while atrophy is a condition of being "shelved," or made inactive and lifeless.

Keep Reading on Vocabulary.com

Vocabulary lists containing atrophy

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Measures of gray matter atrophy were still the strongest overall predictors of cognitive ability.

From Science Daily ● Sep. 14, 2026

One reason employers are hesitant to hire those who have been out of the workforce for a prolonged period of time is that they believe skills atrophy.

From MarketWatch ● Aug. 26, 2026

Human brains function on a pretty strict use-it-or-lose-it policy: When they’re not engaged, they start to atrophy.

From Salon ● Jun. 10, 2026

Apitegromab works by blocking a protein involved in the breakdown of muscle and is also being explored as a treatment for other medical conditions affecting muscles, including spinal muscular atrophy.

From BBC ● Jun. 8, 2026

The psyche can be bombarded only so much by these rhythms before it begins to crumble and atrophy.

From "A Confederacy of Dunces" by John Kennedy Toole

Like any skill, it atrophies when we outsource the work.

From The Wall Street Journal ● Mar. 27, 2026

"When you get machines thinking for you, your brain just atrophies."

From BBC ● Jul. 10, 2025

As we age, our brain gradually atrophies, losing nerve cells and connections and this can lead to a decline in brain function.

From Science Daily ● Feb. 6, 2024

If astrophysicists don’t take big, new and different swings at dark matter, the search will only stagnate until it atrophies.

From Scientific American ● Apr. 5, 2023

Genuflexion before the idol or the dollar atrophies the muscle which walks and the will which moves.

From Morals and Dogma of the Ancient and Accepted Scottish Rite of Freemasonry by Albert Pike

“We think there’s a multidecade need to rebuild some of that capability that has just atrophied over the years,” Fujiyama said, citing a near-term dearth of munitions and hypersonic weapons in particular.

From The Wall Street Journal ● Aug. 19, 2026

John’s left arm had atrophied, his hand now basically a claw, and two of his fingers were numb.

From Los Angeles Times ● Aug. 16, 2026

The pandemic, for all its lessons, quietly atrophied some of our neighboring muscles, and many of us are still figuring out how to use them again.

From Salon ● Jan. 19, 2026

Social skills and conversational ease have stiffened and atrophied.

From New York Times ● May 14, 2024

The hollow bolted around the bend, using its muscular tongues like legs, its atrophied human limbs hanging useless.

From "Hollow City" by Ransom Riggs

“My hunch is that we’re atrophying our brains,” says Wolkowitz, 38.

From The Wall Street Journal ● Sep. 30, 2026

After exhausting holistic options, he saw a doctor who said one of his vocal cords was atrophying.

From Seattle Times ● Apr. 23, 2024

"After two years, part of my brain was atrophying," one said.

From BBC ● Feb. 4, 2024

The work the body does against gravity to stay upright and move around keeps muscles from atrophying and stimulates bone growth.

From Scientific American ● Sep. 19, 2023

Over the weeks that followed he languished in the hospital, arms curled grotesquely at his sides, muscles atrophying, his weight dropping below 80 pounds.

From "Into Thin Air" by Jon Krakauer

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