base-pairing rules

plural noun

Genetics.

1. constraints imposed by the molecular structure of DNA and RNA on the formation of hydrogen bonds among the four purine and pyrimidine bases such that adenine pairs with thymine or uracil, and guanine pairs with cytosine.

Example Sentences

They are designed to replace faulty RNA during the transcription process by snapping into place according to the standard base-pairing rules and thereby tweaking protein production.

Read more on Scientific American

To this complex the researchers tethered an enzyme, APOBEC1, which triggers a series of chemical reactions that ultimately change C to T. DNA's base-pairing rules, which specify that a T on one DNA strand pairs with an A on the opposite strand, govern a subsequent change.

Read more on Science Magazine

The concept behind DNA origami was laid down in the early 1980s by crystallographer Nadrian Seeman, who realized that the ability of DNA molecules to carry and transfer information according to strict base-pairing rules could be used to rationally assemble structures with precisely controlled nanoscale features.

Read more on Nature

When To Use

What are base-pairing rules?

Base-pairing rules are the principles that govern which nitrogen bases (or nucleobases) bind together in DNA and RNA structures. A nitrogen base is a molecule that contains nitrogen and has the properties of a base (a kind of organic compound).In this case, the word rule just refers to a certain pattern that nitrogen bases tend to follow. There are five bases that make up DNA and RNA strands: adenine, thymine, cytosine, guanine, and uracil.The rules state that adenine always pairs with thymine (or uracil in RNA) and that cytosine always pairs with guanine. Each base in a pair is called a complementary base: adenine and cytosine are complementary bases and cytosine and guanine are complementary bases.