conformation

American  

[kon-fawr-mey-shuhn] / ˌkɒn fɔrˈmeɪ ʃən /

noun

1. manner of formation; structure; form, as of a physical entity.

   Synonyms:

   shape, configuration

2. symmetrical disposition or arrangement of parts.

3. the act or process of conforming; adaptation; adjustment.

4. the state of being conformed.

5. Chemistry. an atomic spatial arrangement that results from rotation of carbon atoms about single bonds within an organic molecule. (configuration ).

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conformation British  

/ ˌkɒnfɔːˈmeɪʃən /

noun

1. the general shape or outline of an object; configuration

2. the arrangement of the parts of an object

3. the act or state of conforming

4. chem

   1. another name for configuration

   2. one of the configurations of a molecule that can easily change its shape and can consequently exist in equilibrium with molecules of different configuration

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Other Word Forms

• conformational adjective

Etymology

Origin of conformation

1505–15; < Latin confōrmātiōn- (stem of confōrmātiō ), equivalent to confōrmāt ( us ) past participle of confōrmāre to shape ( con- con- + fōrm ( a ) form + -āt ( us ) -ate ¹ ) + -iōn- -ion

Explanation

Conformation can mean following the rules, or fitting in. Competitions require conformation from competitors who must follow the rules of the game. You might note water's conformation to the shape of whatever container that holds it. Conformation has its base in the word conform, which means to follow the rules, or behave in such a way that you fit in, in a social or a spatial way (i.e. adjusting to something else's contours). Conformation should not be confused with confirmation, which means showing the truth or accuracy of something. The two words do have similar religious meanings though. Conformation refers to complying with the rules of a church, while confirmation means a person's full entry into the Christian belief.

Example Sentences

"Realizing that protein conformation depends on location gives us multiple ways to engineer cellular function," says Daniel Scholl, first author and former postdoctoral researcher in the Lasker and Deniz labs.

From Science Daily • Feb. 26, 2026

Some fans have received conformation of their success in the ticket ballot, with fans taking to TikTok to share their joy.

From BBC • Feb. 10, 2026

Previous studies have shown that mammalian cells express several hundreds of molecular chaperones, proteins that preserve or change the three-dimensional conformation of existing proteins.

From Science Daily • Apr. 30, 2024

Previous structures from X-ray crystallization revealed that formins are made of two identical parts that encircle the actin filament in a ring-like conformation and step along it as it grows.

From Science Daily • Apr. 16, 2024

At least with our level of chemical intuition, there was unlikely to be any single conformation much prettier than the rest.

From "Double Helix" by James D. Watson