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Synonyms

disease

American  
[dih-zeez] / dɪˈziz /

noun

  1. a disordered or incorrectly functioning organ, part, structure, or system of the body resulting from the effect of genetic or developmental errors, infection, poisons, nutritional deficiency or imbalance, toxicity, or unfavorable environmental factors; illness; sickness; ailment.

    Synonyms:
    malady, disorder, infirmity, indisposition, distemper, derangement, complaint, morbidity
    Antonyms:
    health
  2. any abnormal condition in a plant that interferes with its vital physiological processes, caused by pathogenic microorganisms, parasites, unfavorable environmental, genetic, or nutritional factors, etc.

  3. any harmful, depraved, or morbid condition, as of the mind or society.

    His fascination with executions is a disease.

  4. decomposition of a material under special circumstances.

    tin disease.


verb (used with object)

diseased, diseasing
  1. to affect with disease; make ill.

    Antonyms:
    cure
disease British  
/ dɪˈziːz /

noun

  1. any impairment of normal physiological function affecting all or part of an organism, esp a specific pathological change caused by infection, stress, etc, producing characteristic symptoms; illness or sickness in general

  2. a corresponding condition in plants

  3. any situation or condition likened to this

    the disease of materialism

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Other Word Forms

  • diseasedly adverb
  • diseasedness noun

Etymology

Origin of disease

First recorded in 1300–50; Middle English disese, from Anglo-French dese(a)se, disaise; dis- 1 + ease

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Excessive rainfall creating disease issues for beans limited the amount of cocoa coming out of West African ports.

From The Wall Street Journal • Apr. 3, 2026

Inflammatory bowel disease, which includes ulcerative colitis and Crohn's disease, has not been studied extensively when it comes to diet.

From Science Daily • Apr. 3, 2026

Doctors have long measured cholesterol levels to assess the risk of heart disease.

From The Wall Street Journal • Apr. 3, 2026

Scientists are exploring how snake venom could address cancer, strokes and Alzheimer’s disease, she said.

From Los Angeles Times • Apr. 1, 2026

Malaria was the most feared and the most prevalent disease in the Amazon.

From "Death on the River of Doubt" by Samantha Seiple