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  • drug
    drug
    noun
    a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being.
  • Drug
    Drug
    noun
    the cosmic principle of disorder and falsehood.
Synonyms

drug

1 American  
[druhg] / drʌg /

noun

drugs plural
  1. Pharmacology. a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being.

  2. (in federal law)

    1. any substance recognized in the official pharmacopoeia or formulary of the nation.

    2. any substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in humans or other animals.

    3. any article, other than food, intended to affect the structure or any function of the body of humans or other animals.

    4. any substance intended for use as a component of such a drug, but not a device or a part of a device.

  3. a habit-forming medicinal or illicit substance, especially a narcotic.

  4. drugs,

    1. chemical substances prepared and sold as pharmaceutical items, either by prescription or over the counter.

    2. personal hygienic items sold in a drugstore, as toothpaste, mouthwash, etc.

  5. Obsolete. any ingredient used in chemistry, pharmacy, dyeing, or the like.


verb (used with object)

drugged, drugging
  1. to administer a medicinal drug to.

  2. to stupefy or poison with a drug.

  3. to mix (food or drink) with a drug, especially a stupefying, narcotic, or poisonous drug.

  4. to administer anything nauseous to.

verb phrase

  1. drug up to take a drug, especially an illegal drug: athletes who drug up in the off-season.

    kids hiding under the school bleachers to drug up;

    athletes who drug up in the off-season.

idioms

  1. drug on the market, a commodity that is overabundant or in excess of demand in the market. Also drug in the market.

drug 2 American  
[druhg] / drʌg /

verb

Nonstandard: Chiefly Midland and Southern U.S.
  1. a simple past tense and past participle of drag.


Drug 3 American  
[droog] / drʊg /

noun

Zoroastrianism.
  1. the cosmic principle of disorder and falsehood.


drug British  
/ drʌɡ /

noun

  1. any synthetic, semisynthetic, or natural chemical substance used in the treatment, prevention, or diagnosis of disease, or for other medical reasons

  2. a chemical substance, esp a narcotic, taken for the pleasant effects it produces

  3. a commodity available in excess of the demands of the market

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to mix a drug with (food, drink, etc)

  2. to administer a drug to

  3. to stupefy or poison with or as if with a drug

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
drug Scientific  
/ drŭg /
  1. A chemical substance, especially one prescribed by a medical provider, that is used in the diagnosis, treatment, or prevention of a condition or disease. Drugs are prescribed for a limited amount of time, as for an acute infection, or on a regular basis for chronic disorders, such as hypertension.

  2. A chemical substance such as a narcotic or a hallucinogen that affects the central nervous system and is used recreationally for perceived desirable effects on personality, perception, or behavior. Many recreational drugs are used illicitly and can be addictive.


Other Word Forms

Derived Forms

Inflected Forms

Nouns

Etymology

Origin of drug1

First recorded in 1300–50; Middle English drogges (plural), from Middle French drogue, of obscure origin

Origin of Drug3

From the Avestan word drauga

Explanation

A drug is a medicine. Before you travel to India, your doctor may prescribe a drug to protect you from getting malaria. A substance that makes a change in your body is a drug. Most often, a drug is medicine prescribed by a doctor to protect a patient from illness, cure them, or relieve their pain. Drug also means an illegal substance taken simply for the way it makes the user feel. Drug is also a verb that describes both taking illegal drugs and giving someone a drug secretly, such as slipping it into their food or drink.

Keep Reading on Vocabulary.com

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Since returning to office in 2025, US President Donald Trump has intensified efforts against Latin American drug cartels and their operations.

From BBC Jul. 28, 2026

The Centers for Medicare and Medicaid Services has said it started the program in 2025 to hold drug prices steady.

From MarketWatch Jul. 28, 2026

The pharmaceutical industry, meanwhile, was eager to create “the next blockbuster drug, something on the order of Thorazine and Valium.”

From The Wall Street Journal Jul. 28, 2026

Medicare is scrapping a temporary program that helped keep the price of monthly premiums in check for older adults with Part D prescription drug plans.

From MarketWatch Jul. 28, 2026

Until I know the drug test results, I feel obliged to keep looking for jobs.

From "Nickel and Dimed: On (Not) Getting By in America" by Barbara Ehrenreich

The panel assembled to advise the US Food and Drug Administration backed semax and epitalon on Friday.

From Barron's Jul. 24, 2026

Food and Drug Administration announced it was initiating a traceback investigation into a second cyclosporiasis outbreak.

From Los Angeles Times Jul. 24, 2026

Food and Drug Administration recently extended its deadline to decide on the drug’s authorization to review updated results from the clinical trial that was the basis for AstraZeneca’s regulatory submissions, the company said.

From The Wall Street Journal Jul. 23, 2026

The case came to light after officials from the Ministry of Food and Drug Safety found reviews that diners had posted online with photographs of dishes sprinkled with ants.

From BBC Jul. 22, 2026

She had made it with a penny test tube bought at Knipe’s Drug Store.

From "A Tree Grows in Brooklyn" by Betty Smith

Soon it will increasingly help discover new knowledge—from discovering new drugs to cure a family member’s disease to finding new ways to improve your business.

From The Wall Street Journal Jul. 28, 2026

In the past 10 years the drugs have increasingly been made available to more cancer patients in Northern Ireland.

From BBC Jul. 28, 2026

Investments will follow market access to the most innovative drugs, and countries that five or ten years ago would have approved medicines later than Europe are now moving faster, he says.

From The Wall Street Journal Jul. 28, 2026

Last month's trial results showed that its new pill appears to help people lose a similar amount of weight to other GLP-1 oral drugs.

From Barron's Jul. 27, 2026

Those companies that did make MDR drugs could pretty much name their own price.

From "Mountains Beyond Mountains" by Tracy Kidder and Michael French

Had Raynella drugged him and staged an accident?

From The Wall Street Journal May 1, 2026

"He arrived with brain trauma, sedated, drugged, breathing with a ventilator," Interior Minister Armando Benedetti said.

From Barron's Oct. 19, 2025

Mr. Olson was working at Fort Detrick and was unwittingly drugged with LSD in a CIA mind-control experiment that ended with him falling to his death from a New York hotel window.

From Washington Times Dec. 6, 2023

Cohen has pointed out there is no forensic evidence that anyone was drugged and noted that all but one of the women waited more than a decade to report their alleged assault to law enforcement.

From Los Angeles Times May 16, 2023

The warm room lulled his blood and a deepening sense of fatigue drugged him with sleep.

From "Native Son" by Richard Wright

With her brown bobbed haircut and round sunglasses, Pelicot has become an international feminist symbol, inspiring a change to French rape laws and a public reckoning with the problem of drugging women.

From Barron's Feb. 11, 2026

If there is widespread dog drugging, I certainly didn’t find that or hear about it, and I asked some questions along those lines.

From Salon Apr. 23, 2024

This new information could prove to be especially useful to drug developers hoping to create a new cancer treatment by drugging this interaction.

From Science Daily Nov. 15, 2023

The law sets minimum standards of care that nursing homes must meet to receive Medicaid reimbursement, and it specifically prohibits drugging nursing home residents for “purposes of discipline or convenience.”

From Seattle Times Nov. 29, 2022

The careful hygienic and dietetic treatment, combined with the least amount of drugging, is the best and most rational method of treatment.

From Arteriosclerosis and Hypertension: with Chapters on Blood Pressure, 3rd Edition. by Warfield, Louis Marshall

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