[ en-doh-noo-klee-eys, -eyz, -nyoo- ]
/ ˌɛn doʊˈnu kliˌeɪs, -ˌeɪz, -ˈnyu- /

noun Biochemistry.

any of a group of enzymes that degrade DNA or RNA molecules by breaking linkages within the polynucleotide chains.

Origin of endonuclease

First recorded in 1960–65; endo- + nuclease
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020

British Dictionary definitions for endonuclease

/ (ˌɛndəʊˈnjuːklɪˌeɪz) /


an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotideCompare exonuclease
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medical definitions for endonuclease

[ ĕn′dō-nōōklē-ās′, -āz′ ]


Any of a group of enzymes that catalyze the hydrolysis of phosphodiester bonds between nucleic acids in a DNA molecule or RNA sequence.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.