endonuclease

American  

[en-doh-noo-klee-eys, -eyz, -nyoo-] / ˌɛn doʊˈnu kliˌeɪs, -ˌeɪz, -ˈnyu- /

noun

Biochemistry.

1. any of a group of enzymes that degrade DNA or RNA molecules by breaking linkages within the polynucleotide chains.

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endonuclease British  

/ ˌɛndəʊˈnjuːklɪˌeɪz /

noun

1. an enzyme that is responsible for scission of a nucleic acid chain, the action of which is not confined to the terminal nucleotide Compare exonuclease

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Etymology

Origin of endonuclease

First recorded in 1960–65; endo- + nuclease

Example Sentences

The paper is titled "Activation of CBASS-Cap5 endonuclease immune effector by cyclic nucleotides."

From Science Daily • Feb. 6, 2024

But the challenge was how to introduce the endonuclease gene and its associated genetic payload to a spot in the genome where it would work safely without inadvertently affecting other aspects of the animal’s physiology.

From Scientific American • Jan. 13, 2023

Researchers need only an enzyme that cuts DNA, such as the endonuclease Cas9, and a guide RNA molecule that directs the enzyme to cut the gene of interest.

From Nature • Sep. 26, 2017

High-molecular-weight DNA was isolated and labelled from leaf tissue of three-week old quinoa plants according to standard BioNano protocols, using the single-stranded nicking endonuclease Nt.BspQI.

From Nature • Feb. 7, 2017

Mosaic mutant F0 fish were outcrossed to AB wild-type fish and embryos were batch genotyped for transmission of the mutation using PCR and T7 endonuclease.

From Nature • Dec. 13, 2016