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Synonyms

mainline

American  
[meyn-lahyn, -lahyn] / ˈmeɪnˌlaɪn, -ˈlaɪn /

verb (used without object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject a narcotic, especially heroin, directly into a vein.

  2. to use or enjoy something without restriction.

    to mainline on TV movies.


verb (used with object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject (a narcotic, especially heroin) directly into a vein.

  2. to use, enjoy, or imbibe (something) without restriction.

    mainlining coffee all day long.

adjective

  1. having a principal, established, or widely accepted position; major; mainstream.

    the membership of mainline churches.

Other Word Forms

Etymology

Origin of mainline

1935–40, v., adj. use of main line

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The game will launch on current-generation consoles, PC and Nintendo Switch 2, marking the first mainline Call of Duty to skip PlayStation 4 and Xbox One.

From BBC • May 29, 2026

Last year, he moved to North Carolina for a job with Christian Brothers Automotive, making $23 an hour and working more than 50 hours a week as a mainline technician, primarily servicing BMWs.

From The Wall Street Journal • Apr. 22, 2026

It is the main station for all services on the west coast mainline to England and also operates services throughout central Scotland.

From BBC • Mar. 10, 2026

The genius of hit songs, beyond technical artistry—and the vagaries of timing—is the ability to mainline emotion.

From The Wall Street Journal • Mar. 5, 2026

Black Muslims came in many stripes, from mainline Nation of Islam to the splinter Five Percenters.

From "Newjack: Guarding Sing Sing" by Ted Conover

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