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phosphorylate

American  
[fos-fer-uh-leyt, fos-fawr-uh-, -for-] / ˈfɒs fər əˌleɪt, fɒsˈfɔr ə-, -ˈfɒr- /

verb (used with object)

Chemistry.
phosphorylated, phosphorylating
  1. to introduce the phosphoryl group into (an organic compound).


Other Word Forms

Etymology

Origin of phosphorylate

First recorded in 1930–35; phosphor- + -yl + -ate 1

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Interestingly, even in mice that don't produce CDKL5, there was still some EB2 phosphorylation taking place, which suggested that another similar enzyme must also be able to phosphorylate it.

From Science Daily Feb. 8, 2024

Various kinases are named for the substrate they phosphorylate.

From Textbooks Jun. 9, 2022

On the intracellular side, the ends of peptide chains on each protein phosphorylate the other member of the pair, providing active docking sites that initiate cellular responses.

From Textbooks Jun. 9, 2022

The authors discovered that mitochondrial dysfunction caused HRI to phosphorylate eIF2α even when haem was plentiful, which was surprising, given that HRI activation had been thought to depend on haem depletion11,12.

From Nature Mar. 3, 2020

In the final step, these protein kinases phosphorylate proteins in the cytoplasm.

From Textbooks Jun. 19, 2013

Furthermore, they observed an association between increasing neural activity electrically or chemically and an increase in the amount of phosphorylated α-synuclein in both cultured cells and in mouse brain tissue.

From Science Daily Jan. 9, 2024

The researchers then recorded from the calcium channels to see what was happening when they were not being phosphorylated by CDKL5.

From Science Daily Dec. 11, 2023

In humans, if PGM1 is mutated at one of these sites and can’t be phosphorylated, it causes the person to fatigue easily, Olsen explains.

From Scientific American Feb. 24, 2023

These are considered less accurate than imaging or spinal fluid tests that measure two types of proteins, beta-amyloid and phosphorylated tau, which accumulate abnormally in the brains of people with Alzheimer’s.

From Washington Post Sep. 15, 2022

The phosphorylated molecule is at a higher-energy state and is less stable than its unphosphorylated form, and this added energy from the addition of the phosphate allows the molecule to undergo its endergonic reaction.

From Textbooks Jun. 9, 2022

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