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predispose

American  
[pree-di-spohz] / ˌpri dɪˈspoʊz /

verb (used with object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give an inclination or tendency to beforehand; make susceptible.

    Genetic factors may predispose human beings to certain metabolic diseases.

    Synonyms:
    prepare, prearrange
  2. to render subject, susceptible, or liable.

    The evidence predisposes him to public censure.

  3. to dispose beforehand.

    Synonyms:
    incline, bias
  4. Archaic. to dispose of beforehand, as in a will, legacy, or the like.


verb (used without object)

  • predisposes,
    present (3rd person singular)
  • predisposed,
    past participle,  past
  • predisposing
    present participle
  1. to give or furnish a tendency or inclination.

    an underground job that predisposes to lung infection.

predispose British  
/ ˌpriːdɪˈspəʊz /

verb

  1. to incline or make (someone) susceptible to something beforehand

  2. law to dispose of (property, etc) beforehand; bequeath

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

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Etymology

Origin of predispose

First recorded in 1640–50; pre- + dispose

Explanation

Predispose means to have a tendency toward something. Some people believe that just being born in Canada will predispose you to love ice hockey. Many situations or events can predispose you to have a particular reaction, opinion, or feeling. Being bitten by a dog as a child could predispose you to having a fear of dogs. Having ancestors with great athletic ability might predispose you to enjoy running. If you want to predispose your father to liking your new boyfriend, be sure to tell him about volunteering at the food bank and leave out the bits about his arrest and dropping out of school.

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Vocabulary lists containing predispose

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Research by UC San Francisco’s Sharon suggests migraine headaches predispose people to BPPV, by causing crystals to dislodge from their normal location.

From The Wall Street Journal ● Apr. 15, 2026

"The whole team undertakes a standardized warm-up that addresses a number of physical concerns that predispose our female athletes to ACLs," she said.

From BBC ● Jun. 30, 2025

Nothing in her environment would predispose her to cancer, except for being in close proximity to the fires.

From Slate ● Jan. 16, 2025

“But unfortunately, when it makes that change in cell type, there are genetic changes that predispose a patient to cancer.”

From Los Angeles Times ● Sep. 16, 2024

Attitudes such as these certainly predispose one to innumeracy.

From "Innumeracy: Mathematical Illiteracy and Its Consequences" by John Allen Paulos

The condition turns up in 10% to 20% of people in their 70s, and predisposes them to blood cancer and, surprisingly, heart disease, likely driven by the inflammation these rogue cells provoke.

From The Wall Street Journal ● Apr. 20, 2026

Studies show that adding sugar to any food for babies or small children predisposes them to having a sweet tooth.

From Salon ● Apr. 25, 2024

This predisposes them to developing the disease but in itself is not symptomatic.

From Science Daily ● Apr. 22, 2024

People with two copies of the APOE4 gene, which predisposes to Alzheimer’s, may be at higher risk of ARIA.

From Science Magazine ● Jan. 6, 2023

When continually resorted to by persons well nourished, but inactive, it is apt to produce a flaccidity of the system, and to encourage that relaxation of the veins which predisposes to excessive formation of fat.

From Harper's New Monthly Magazine, Volume 1, No. 2, July, 1850. by Various

To investigate, the researchers studied mice genetically predisposed to developing intestinal cancer.

From Science Daily ● Oct. 6, 2026

Certain breeds are predisposed to heart or orthopedic issues, for example, that can be expensive to treat.

From MarketWatch ● Sep. 15, 2026

When that fan base is predisposed to wanting to stick it to the man, it’s not a tough sell.

From Los Angeles Times ● Jun. 16, 2026

What's more, With Love, Meghan was never going to change opinions of those who are already, for whatever reason, predisposed against her - just as her new podcast series is unlikely to.

From BBC ● Apr. 6, 2025

Sedentary villages based on cereals were already in existence before the rise of food production and predisposed those hunter-gatherers to agriculture and herding.

From "Guns, Germs, and Steel: The Fates of Human Societies" by Jared M. Diamond

However, the new study indicates that, without simultaneous maternal pulse recording, this method is a significant risk factor predisposing the fetus to labour-related hypoxia and its long-term neurological effects.

From Science Daily ● Jan. 30, 2024

“The difference is likely due to a combination of stress and inflammation, arising from predisposing factors and the way this virus biologically interacts with the cardiovascular system.”

From Seattle Times ● Oct. 26, 2022

Many species of Sorbus have a small population size, predisposing them to threatening events.

From BBC ● Sep. 26, 2021

“Climate change is predisposing the fuels into drier conditions,” Stephens said.

From Los Angeles Times ● Oct. 6, 2020

Was there anything about the Chinese environment predisposing toward Confucian philosophy and cultural conservatism, which may also have profoundly affected history?

From "Guns, Germs, and Steel: The Fates of Human Societies" by Jared M. Diamond

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