smallpox
Americannoun
noun
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A highly infectious and often fatal disease caused by the variola virus of the genus Orthopoxvirus and characterized by fever, headache, and severely inflamed skin sores that result in extensive scarring. Once a dreaded killer of children that caused the deaths of millions of Native Americans after the arrival of European settlers in the Americas, smallpox was declared eradicated in 1980 following a worldwide vaccination campaign. Samples of the virus have been preserved in laboratories in the United States and Russia.
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Also called variola
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See Note at Jenner
Discover More
Today, the smallpox virus exists only in laboratories.
A surface with many blemishes is sometimes said to be “pockmarked” because it resembles the skin of a smallpox sufferer.
The use of smallpox is a major concern in the area of bioterrorism (see also bioterrorism).
Smallpox is the first disease of humans to be completely eradicated by a worldwide campaign of inoculation.
Etymology
Origin of smallpox
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
“The Doctors’ Riot of 1788” centers on the New York incident but also tells the broader story of medicine in the early American republic, including quack cures and smallpox panics.
Health officials relied on smallpox vaccines to protect those most vulnerable, but these vaccines are costly and difficult to manufacture because they use a whole, weakened virus.
From Science Daily
Though the conquistadors enjoyed superior technology, including steel weapons and gunpowder, European diseases such as smallpox and measles proved more decisive, taking untold millions of indigenous lives.
In 1855, Massachusetts became the first state to require that children receive a smallpox vaccine before attending school.
From Salon
The U.S. has eradicated only one human infectious disease, which is smallpox, and that was done through vaccination, according to the Centers for Disease Control and Prevention.
From Los Angeles Times
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.