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a combining form meaning “hard,” used with this meaning, and as a combining form of sclera, in the formation of compound words:
Also, especially before a vowel, scler-.
Origin of sclero-
combining form of Greek sklērós hard Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2018.
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British Dictionary definitions for sclero-


combining form
indicating hardness: sclerosis
of or relating to the sclera: sclerotomy
Word Origin
from Greek sklēros hard
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word Origin and History for sclero-

before vowels scler-, word-forming element meaning "hard," from Latinized form of Greek sklero-, comb. form of skleros "hard," related to skellein "to dry up, parch," from PIE *skle-ro-, from root *skele- "to parch, wither."

Online Etymology Dictionary, © 2010 Douglas Harper
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sclero- in Medicine

sclero- or scler-

  1. Hard: scleredema.

  2. Hardness: sclerogenous.

  3. Sclera: scleritis.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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