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  • mayo
    mayo
    noun
  • Mayo
    Mayo
    noun
    Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.
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Slang dictionary results for mayo.

mayo

1 American  
[may-oh] / ˈmeɪ oʊ /

noun

Informal.
  1. mayonnaise.


Mayo 2 American  
[may-oh] / ˈmeɪ oʊ /

noun

  1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

  2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.


Mayo 1 British  
/ ˈmeɪəʊ /

noun

  1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Mayo 2 British  
/ ˈmeɪəʊ /

noun

  1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Unlike bleach and wipes, a product made of buttermilk and mayo is not exactly designed for mass consumption.

From The Wall Street Journal ● Jul. 17, 2026

In the episode, Celenza uses the two for a breakfast sandwich, but mayo and hot sauce can be used in a multitude of meals: sandwiches, salads, marinades, hamburgers, tacos… do I need to keep going?

From Salon ● Jul. 2, 2026

A single distribution network that served them with small packets of shampoo as well as jars of mayo made sense.

From The Wall Street Journal ● Mar. 20, 2026

I made a mayo line because: there’s such a delta between a sandwich made in the average American home and one made in great sandwich shops.

From The Wall Street Journal ● Feb. 11, 2026

Dad held up a knife covered with mayo.

From "Lawn Boy" by Gary Paulsen

You should not treat the $500,000 as “a standalone pile of money,” said James Mayo, a certified financial planner and principal of IronFjord Wealth Management.

From MarketWatch ● Oct. 3, 2026

Esophagitis is inflammation of the tissues that line the esophagus, per the Mayo Clinic.

From Los Angeles Times ● Sep. 18, 2026

In a post on X, Wiles said her pathology tests "came back clear" after a visit to the Mayo Clinic earlier this week.

From BBC ● Sep. 16, 2026

A Mayo Clinic study found that nearly one in five youth who suffered sudden cardiac arrest or sudden cardiac death reported routine energy-drink use.

From The Wall Street Journal ● Sep. 15, 2026

The man in the boat says his name is Tim Boyle from Mayo God help us and we docked there at the right time because there’s a bit of a party and we’re all invited.

From "Angela's Ashes: A Memoir" by Frank McCourt

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