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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[mey-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[mey-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

Example Sentences

See Examples For:

mayo Mayo

Burger King, owned by Restaurant Brands International, earlier this year improved the bun, box, mayo and other elements of its Whopper.

From The Wall Street Journal ● Aug. 6, 2026

Unlike bleach and wipes, a product made of buttermilk and mayo is not exactly designed for mass consumption.

From The Wall Street Journal ● Jul. 17, 2026

The first episode, which dropped earlier this month, teaches viewers how to make homemade mayo and hot sauce.

From Salon ● Jul. 2, 2026

The swap is simple: use yogurt in place of some or all of the mayo.

From Salon ● Apr. 28, 2026

“You mean the rat in my backpack when you know I’m scared of them? The mayo in my shampoo? What about stealing my lunch money?”

From "Witchlings" by Claribel A. Ortega

Ruddarraju and Mayo both played key roles in building Musk’s Colossus supercomputers in Memphis.

From The Wall Street Journal ● Aug. 25, 2026

“It is kind of like the anti-Jamie Dimon,” Mayo said.

From The Wall Street Journal ● Aug. 17, 2026

What neither trial’s critics nor defenders noticed at the time: Pauling and Cameron had started with vitamin C into a vein; the Mayo Clinic trials used tablets only.

From Science Daily ● Aug. 7, 2026

According to the Mayo Clinic, CTE cannot be diagnosed definitively during life.

From Los Angeles Times ● Jul. 30, 2026

After leaving the Mayo Clinic, Gey spent several days in New York City at Sloan-Kettering for another study, and he underwent chemotherapy at Hopkins using a drug not yet approved for use in humans.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot