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Synonyms

mainline

American  
[meyn-lahyn, -lahyn] / ˈmeɪnˌlaɪn, -ˈlaɪn /

verb (used without object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject a narcotic, especially heroin, directly into a vein.

  2. to use or enjoy something without restriction.

    to mainline on TV movies.


verb (used with object)

Slang.
mainlines, present (3rd person singular) mainlined, past participle, past mainlining present participle
  1. to inject (a narcotic, especially heroin) directly into a vein.

  2. to use, enjoy, or imbibe (something) without restriction.

    mainlining coffee all day long.

adjective

  1. having a principal, established, or widely accepted position; major; mainstream.

    the membership of mainline churches.

Other Word Forms

Etymology

Origin of mainline

1935–40, v., adj. use of main line

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The game will launch on current-generation consoles, PC and Nintendo Switch 2, marking the first mainline Call of Duty to skip PlayStation 4 and Xbox One.

From BBC • May 29, 2026

“We’ve made it kind of core to who Allegiant is to seek out opportunities that aren’t typically served by mainline carriers,” said Drew Wells, the airline’s chief commercial officer.

From The Wall Street Journal • May 17, 2026

The service has been installed on regional jets and United says it will be on 50% of its mainline fleet by the end of the year and 100% next year.

From The Wall Street Journal • Apr. 25, 2026

There had been nothing going out on the West Coast mainline and hardly any announcements, she said.

From BBC • Nov. 21, 2025

But over the last forty years, evangelicals have pulled steadily closer in income and education to mainline Protestants in the historically affluent establishment denominations.

From "Class Matters" by The New York Times

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