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atrophy

American  
[a-truh-fee] / ˈæ trə fi /

noun

  • atrophies
    plural
  1. Pathology. Also atrophia a wasting away of the body or of an organ or part, as from defective nutrition or nerve damage.

  2. degeneration, decline, or decrease, as from disuse.

    He argued that there was a progressive atrophy of freedom and independence of thought.


verb (used with or without object)

  • atrophies,
    present (3rd person singular)
  • atrophied,
    past participle,  past
  • atrophying
    present participle
  1. to affect with or undergo atrophy.

atrophy British  
/ ˈætrəfɪ, əˈtrɒfɪk /

noun

  1. a wasting away of an organ or part, or a failure to grow to normal size as the result of disease, faulty nutrition, etc

  2. any degeneration or diminution, esp through lack of use

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to waste away or cause to waste away

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
atrophy Scientific  
/ ătrə-fē /
  1. A wasting or decrease in the size of an organ or tissue, as from death and reabsorption of cells, diminished proliferation of cells, pressure, lack of oxygen, malnutrition, decreased function, or hormonal changes.


atrophy Cultural  
  1. The wasting away or decrease in size of an organ or tissue in the body. When a body part is affected by paralysis, the muscles may atrophy through lack of use.


Discover More

The term is also used in a more general way to refer to a wasting process: “Since he stopped playing, his piano skills have atrophied.”

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Etymology

Origin of atrophy

First recorded in 1590–1600; earlier atrophie, from Middle French, from Late Latin atrophia, from Greek, from átroph(os) “not fed, unnourished” (from a- a- 6 + troph(ḗ) “nourishment” + -os, adjective suffix; see tropho-) + -ia -ia

Explanation

Wearing a cast on a broken leg can cause atrophy, or withering, in the leg, because it is immobilized and gets no exercise. Appearing in English in the 17th century, the word atrophy originally described a lack of nourishment. Atrophy occurs in parts of the body that can't move or be "fed" because of disease or injury. It also is used to describe things that go dull through lack of use, like skills in sports or artistic creativity. The (unrelated) word "trophy" refers to something that sits on a shelf and is admired, while atrophy is a condition of being "shelved," or made inactive and lifeless.

Keep Reading on Vocabulary.com

Vocabulary lists containing atrophy

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

"We found there was less brain atrophy and less tau accumulation, which was very exciting to see."

From Science Daily Jul. 20, 2026

Apitegromab works by blocking a protein involved in the breakdown of muscle and is also being explored as a treatment for other medical conditions affecting muscles, including spinal muscular atrophy.

From BBC Jun. 8, 2026

They’ve become monuments to corporate greed — zones of atrophy, boredom and total disempowerment.

From Salon May 22, 2026

The technology was initially used in hospitals and rehab settings to ease pain, prevent muscle atrophy and improve circulation.

From The Wall Street Journal Apr. 1, 2026

When parts of the body aren’t used, they tend to weaken, or shrink, or atrophy.

From "Flying to the Moon: An Astronaut's Story" by Michael Collins

Despite massive vocal opposition, cognitive offloading is addictive, and our capacity for deep work atrophies with every use.

From The Wall Street Journal May 26, 2026

NBCUniversal is cutting “Access Hollywood” and several other of its daytime talk shows, effectively ending its first run syndication business as daytime television atrophies.

From Los Angeles Times Mar. 13, 2026

"When you get machines thinking for you, your brain just atrophies."

From BBC Jul. 10, 2025

As we age, our brain gradually atrophies, losing nerve cells and connections and this can lead to a decline in brain function.

From Science Daily Feb. 6, 2024

In dementia praecox particularly, he has shown us how auditory symptoms group about temporal atrophies and optical signs with the occipital and so forth and so on.

From The Journal of Abnormal Psychology, Volume 10 by Various

Global trade boomed and the U.S. economy led the growth, even as U.S. shipbuilding atrophied and the Navy dropped from 7,000 ships at the close of World War II to around 300 today.

From The Wall Street Journal Apr. 11, 2026

Our democratic muscles have atrophied, and I hope they can be reinvigorated before it's too late.

From Salon May 5, 2025

Social skills and conversational ease have stiffened and atrophied.

From New York Times May 14, 2024

When followed over several years, the super-agers’ brains atrophied at a slower rate than average.

From Seattle Times Apr. 29, 2024

They are atrophied, probably beyond hope of recovery.

From "The Poisonwood Bible" by Barbara Kingsolver

But the Mayor’s Fund had been atrophying for years, with its donations shrinking to a fraction of what it raised under Mayor Michael Bloomberg.

From The Wall Street Journal Aug. 14, 2026

After exhausting holistic options, he saw a doctor who said one of his vocal cords was atrophying.

From Seattle Times Apr. 23, 2024

"After two years, part of my brain was atrophying," one said.

From BBC Feb. 4, 2024

The work the body does against gravity to stay upright and move around keeps muscles from atrophying and stimulates bone growth.

From Scientific American Sep. 19, 2023

Over the weeks that followed he languished in the hospital, arms curled grotesquely at his sides, muscles atrophying, his weight dropping below 80 pounds.

From "Into Thin Air" by Jon Krakauer

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