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atrophy

American  
[a-truh-fee] / ˈæ trə fi /

noun

  • atrophies
    plural
  1. Pathology. Also atrophia a wasting away of the body or of an organ or part, as from defective nutrition or nerve damage.

  2. degeneration, decline, or decrease, as from disuse.

    He argued that there was a progressive atrophy of freedom and independence of thought.


verb (used with or without object)

  • atrophies,
    present (3rd person singular)
  • atrophied,
    past participle,  past
  • atrophying
    present participle
  1. to affect with or undergo atrophy.

atrophy British  
/ ˈætrəfɪ /

noun

  1. a wasting away of an organ or part, or a failure to grow to normal size as the result of disease, faulty nutrition, etc

  2. any degeneration or diminution, esp through lack of use

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

verb

  1. to waste away or cause to waste away

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
atrophy Scientific  
/ ăt′rə-fē /
  1. A wasting or decrease in the size of an organ or tissue, as from death and reabsorption of cells, diminished proliferation of cells, pressure, lack of oxygen, malnutrition, decreased function, or hormonal changes.


atrophy Cultural  
  1. The wasting away or decrease in size of an organ or tissue in the body. When a body part is affected by paralysis, the muscles may atrophy through lack of use.


Discover More

The term is also used in a more general way to refer to a wasting process: “Since he stopped playing, his piano skills have atrophied.”

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Etymology

Origin of atrophy

First recorded in 1590–1600; earlier atrophie, from Middle French, from Late Latin atrophia, from Greek, from átroph(os) “not fed, unnourished” (from a- a- 6 + troph(ḗ) “nourishment” + -os, adjective suffix; see tropho-) + -ia -ia


Explanation

Wearing a cast on a broken leg can cause atrophy, or withering, in the leg, because it is immobilized and gets no exercise. Appearing in English in the 17th century, the word atrophy originally described a lack of nourishment. Atrophy occurs in parts of the body that can't move or be "fed" because of disease or injury. It also is used to describe things that go dull through lack of use, like skills in sports or artistic creativity. The (unrelated) word "trophy" refers to something that sits on a shelf and is admired, while atrophy is a condition of being "shelved," or made inactive and lifeless.

Keep Reading on Vocabulary.com

Vocabulary lists containing atrophy

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

That limitation has made it much harder to study serious diseases involving the brain stem, including spinal muscular atrophy and amyotrophic lateral sclerosis.

From Science Daily ● Sep. 21, 2026

One reason employers are hesitant to hire those who have been out of the workforce for a prolonged period of time is that they believe skills atrophy.

From MarketWatch ● Aug. 26, 2026

Regeneron has been developing a pipeline of muscle-preservation drugs that block the body’s natural atrophy systems.

From The Wall Street Journal ● Jul. 24, 2026

Human brains function on a pretty strict use-it-or-lose-it policy: When they’re not engaged, they start to atrophy.

From Salon ● Jun. 10, 2026

He massaged Shin’s arms and legs so that his muscles would not atrophy.

From "Escape from Camp 14: One Man's Remarkable Odyssey from North Korea to Freedom in the West" by Blaine Harden

Like any skill, it atrophies when we outsource the work.

From The Wall Street Journal ● Mar. 27, 2026

"When you get machines thinking for you, your brain just atrophies."

From BBC ● Jul. 10, 2025

As we age, our brain gradually atrophies, losing nerve cells and connections and this can lead to a decline in brain function.

From Science Daily ● Feb. 6, 2024

If astrophysicists don’t take big, new and different swings at dark matter, the search will only stagnate until it atrophies.

From Scientific American ● Apr. 5, 2023

For just as the thymus involutes at the second year, the pineal atrophies before the onset of adolescence.

From The Glands Regulating Personality by Louis Berman M.D.

When we met him, he meandered across the field, atrophied by lack of exercise, sat on my foot and looked up with a hopeful demeanor.

From The Wall Street Journal ● Jan. 14, 2026

Any principles beyond those have atrophied into invisibility.

From Salon ● Apr. 20, 2025

Those muscles atrophied, leaving a huge opportunity for someone like Matt.

From Los Angeles Times ● Jan. 19, 2025

Social skills and conversational ease have stiffened and atrophied.

From New York Times ● May 14, 2024

I never learned any prayers, so I wander away into the fields, beyond the gates and watchtowers, as far from the barracks and bodies as my atrophied muscles will carry me.

From "What the Night Sings" by Vesper Stamper

But the Mayor’s Fund had been atrophying for years, with its donations shrinking to a fraction of what it raised under Mayor Michael Bloomberg.

From The Wall Street Journal ● Aug. 14, 2026

After exhausting holistic options, he saw a doctor who said one of his vocal cords was atrophying.

From Seattle Times ● Apr. 23, 2024

"After two years, part of my brain was atrophying," one said.

From BBC ● Feb. 4, 2024

The work the body does against gravity to stay upright and move around keeps muscles from atrophying and stimulates bone growth.

From Scientific American ● Sep. 19, 2023

Over the weeks that followed he languished in the hospital, arms curled grotesquely at his sides, muscles atrophying, his weight dropping below 80 pounds.

From "Into Thin Air" by Jon Krakauer

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