predisposition
Americannoun
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the fact or condition of being predisposed.
a predisposition to think optimistically.
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Medicine/Medical. tendency to a condition or quality, usually based on the combined effects of genetic and environmental factors.
noun
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the condition of being predisposed
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med susceptibility to a specific disease See diathesis
Other Word Forms
- predispositional adjective
Etymology
Origin of predisposition
First recorded in 1615–25; pre- + disposition
Explanation
A predisposition is a tendency to do something. If you know you have a predisposition toward getting carsick, better to plan ahead and avoid eating before a long drive. Things could get ugly. Predisposition comes from the Latin prae meaning "before," and disponere meaning "put in order, arrange, distribute." If you have a predisposition to think or act a certain way, you can anticipate your reaction before it happens. A genetic predisposition means you are likely to inherit a trait from your parents. Someone might have a genetic predisposition to diabetes or to another illness.
Vocabulary lists containing predisposition
"Magic and the Brain," Vocabulary from the magazine article
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The Immortal Life of Henrietta Lacks
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Cosmos
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Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Your ideal rise time is linked to your chronotype, your genetic predisposition to waking at a certain time.
From The Wall Street Journal • Jan. 11, 2026
The Oscar-winning actor announced in 2013 that she had undergone a double mastectomy, followed by a double oophorectomy in 2015, due to her genetic predisposition to cancer.
From Barron's • Dec. 15, 2025
Among other factors, they’ve identified genetic anomalies that may produce a predisposition to the condition.
From Los Angeles Times • Nov. 25, 2025
Genetic predisposition increases disease risk in certain populations.
From Science Daily • Nov. 17, 2025
For a while she’d struggled against her predisposition.
From "Middlesex: A Novel" by Jeffrey Eugenides
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
