irritate
Americanverb (used with object)
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to excite to impatience or anger; annoy.
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Physiology, Biology. to excite (a living system) to some characteristic action or function.
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Pathology. to bring (a body part) to an abnormally excited or sensitive condition.
verb (used without object)
verb
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to annoy or anger (someone)
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(tr) biology to stimulate (an organism or part) to respond in a characteristic manner
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(tr) pathol to cause (a bodily organ or part) to become excessively stimulated, resulting in inflammation, tenderness, etc
Synonym Usage
Irritate, exasperate, provoke mean to annoy or stir to anger. To irritate is to excite to impatience or angry feeling, often of no great depth or duration: to irritate by refusing to explain an action. To exasperate is to irritate to a point where self-control is threatened or lost: to exasperate by continual delays and excuses. To provoke is to stir to a sudden, strong feeling of resentful anger as by unwarrantable acts or wanton annoyance: to tease and provoke an animal until it attacks.
Other Word Forms
Etymology
Origin of irritate
1525–35; < Latin irrītātus, past participle of irrītāre to arouse to anger, excite, aggravate, equivalent to irritā- v. stem + -tus past participle suffix
Explanation
To irritate is to cause an unsettling reaction, whether it's of the body or the nerves. You can irritate someone by talking too loudly on your cellphone in public. You can also irritate your skin, causing a rash or redness. To irritate is to disturb — either physically or psychologically. When you have an allergic reaction to something, you irritate or disturb the body. When you have an allergic reaction to your kid brother, he is probably irritating you with his annoying habits. And what is the result of something irritating? An irritation of course.
Vocabulary lists containing irritate
Because of Winn-Dixie
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Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Short-term exposure can irritate the lungs and nasal passages, and cause nausea and dizziness, said Dr. Regina Chinsio-Kwong, Orange County’s health officer.
From The Wall Street Journal • May 23, 2026
It can irritate the lungs and trigger serious breathing problems.
From Los Angeles Times • Apr. 22, 2026
For more complicated products or ones with ingredients that can irritate the skin if they're not formulated correctly, such as retinols or vitamin C, Dr Bhate recommends sticking to more specialised brands.
From BBC • Dec. 13, 2025
These overstimulated immune cells then move toward the dorsal root ganglia -- the sensory nerve hubs that link the limbs to the spinal cord -- and release inflammatory compounds that irritate and damage nerves.
From Science Daily • Nov. 21, 2025
A training officer named Hill told us that our job would be unusually difficult, because “OJTs irritate inmates.”
From "Newjack: Guarding Sing Sing" by Ted Conover
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
